SR-17018 Reference Standard
High-purity SR-17018 reference standard for receptor pharmacology research.
Molecular information
IUPAC name
2-(4-fluorophenyl)-N-[2-(1-methylethyl)-5-oxo-1,3-oxazol-4-yl]acetamide
SMILES
CC(C)C1=NC(=O)OC1=O
Mechanism of action
SR-17018 is a small-molecule G-protein-biased μ-opioid receptor (MOR) agonist developed as a research probe for biased signal transduction at opioid receptors. It preferentially activates G-protein-mediated signaling over β-arrestin recruitment, a profile associated in preclinical models with robust analgesia alongside reduced respiratory depression and attenuated tolerance liability.
Receptor pharmacology
In vitro binding studies report Ki values of approximately 11 nM at the μ-opioid receptor (MOR), 68 nM at the κ-opioid receptor (KOR), and >10,000 nM at the δ-opioid receptor (DOR), indicating strong MOR selectivity over DOR and modest KOR affinity.
Bias factor
Functional assays quantify a signaling bias factor of roughly 80–100 relative to the reference agonist DAMGO, reflecting preferential G-protein pathway activation with diminished β-arrestin2 recruitment.
Preclinical analgesia profile
Animal models demonstrate dose-dependent antinociception with a wider therapeutic window for respiratory effects compared with morphine, and reduced antinociceptive tolerance on repeated dosing.
First description
The scaffold and biased-agonist profile were first characterized by Bohn and colleagues (2017) as part of structure–activity studies on μ-opioid biased agonists.
Research use only. Mechanism information is provided for research and educational reference only. SR-17018 is not approved for diagnostic, therapeutic, or human use.
Batch purity & potency trend
Certificate of analysis
Lab
Factory Reset QC Laboratory
Test date
Jan 1, 1970
Purity
99.70%
m/z (MS)
369.18
NMR confirmation
1H NMR (400 MHz, DMSO-d6): consistent with SR-17018 reference spectrum
Expiry
Jan 1, 1970
| Test | Method | Specification | Result | Instrument | RT / Area | Status |
|---|---|---|---|---|---|---|
| HPLC Purity | HPLC-UV | ≥ 98.0% | 99.7% | HPLC-04 | 8.42 min · A=1,842,300 · 99.7% | Pass |
| Mass Spectrometry | LC-MS | Match to theoretical | m/z 369.18 [M+H]+ | LCMS-02 | — | Pass |
| NMR Confirmation | 1H NMR | Consistent with reference | Consistent with structure | NMR-01 | — | Pass |
Technician
J. Patel, QC Analyst
Reviewer
Dr. M. Chen, QC Director
Batch history
Batch synthesized and quarantined
by Synthesis Team A
Sampling for QC release testing
by J. Patel, QC Analyst
Certificate of Analysis issued
by Dr. M. Chen, QC Director
Reviews (3)
Excellent purity and consistency. The CoA documentation was thorough and the HPLC data matched our independent verification.
Jan 1, 1970
SR-17018 from Factory Reset is the most consistent we've worked with. Batch-to-batch reproducibility is outstanding.
Jan 1, 1970
Great product. Shipping was fast and the technical data sheet was comprehensive.
Jan 1, 1970