DAMGO Reference Compound
Selective mu-opioid receptor agonist for comparator studies.
Molecular information
IUPAC name
H-Tyr-D-Ala-Gly-NMePhe-Gly-ol
SMILES
CC(C)C1=NC(=O)OC1=O
Mechanism of action
SR-17018 is a small-molecule G-protein-biased μ-opioid receptor (MOR) agonist developed as a research probe for biased signal transduction at opioid receptors. It preferentially activates G-protein-mediated signaling over β-arrestin recruitment, a profile associated in preclinical models with robust analgesia alongside reduced respiratory depression and attenuated tolerance liability.
Receptor pharmacology
In vitro binding studies report Ki values of approximately 11 nM at the μ-opioid receptor (MOR), 68 nM at the κ-opioid receptor (KOR), and >10,000 nM at the δ-opioid receptor (DOR), indicating strong MOR selectivity over DOR and modest KOR affinity.
Bias factor
Functional assays quantify a signaling bias factor of roughly 80–100 relative to the reference agonist DAMGO, reflecting preferential G-protein pathway activation with diminished β-arrestin2 recruitment.
Preclinical analgesia profile
Animal models demonstrate dose-dependent antinociception with a wider therapeutic window for respiratory effects compared with morphine, and reduced antinociceptive tolerance on repeated dosing.
First description
The scaffold and biased-agonist profile were first characterized by Bohn and colleagues (2017) as part of structure–activity studies on μ-opioid biased agonists.
Research use only. Mechanism information is provided for research and educational reference only. SR-17018 is not approved for diagnostic, therapeutic, or human use.
Batch purity & potency trend
Certificate of analysis
Lab
Factory Reset QC Laboratory
Test date
Jan 1, 1970
Purity
98.60%
m/z (MS)
514.31
NMR confirmation
Amino acid composition consistent with H-Tyr-D-Ala-Gly-NMePhe-Gly-ol sequence
Expiry
Jan 1, 1970
| Test | Method | Specification | Result | Instrument | RT / Area | Status |
|---|---|---|---|---|---|---|
| Peptide Purity | HPLC-UV (214 nm) | ≥ 97.0% | 98.6% | HPLC-05 | 12.18 min · A=1,604,900 · 98.6% | Pass |
| Mass Spectrometry | MALDI-TOF | Match to theoretical | m/z 514.31 [M+H]+ | MALDI-01 | — | Pass |
| Amino Acid Analysis | AAA | Consistent with DAMGO sequence | Composition consistent with sequence | AAA-01 | — | Pass |
Technician
L. Okafor, QC Analyst
Reviewer
Dr. M. Chen, QC Director
Batch history
Peptide synthesis completed
by Peptide Synthesis Lab
Lyophilization and QC sampling
by L. Okafor, QC Analyst
Certificate of Analysis issued
by Dr. M. Chen, QC Director
Reviews (1)
DAMGO quality is reliable. Reconstitutes cleanly and performs consistently in binding assays.
Jan 1, 1970